Urinary trypsin inhibitor attenuates lipopolysaccharide-induced neutrophil activation

Urinary trypsin inhibitor attenuates lipopolysaccharide-induced neutrophil activation

BACKGROUND Urinary trypsin inhibitor (UTI), which is speculated to have anti-inflammatory effects, is one of serine protease inhibitors found in human urine and blood. The present study was conducted to clarify the effect of urinary trypsin inhibitor (UTI) on human neutrophil activation and its intracellular signaling mechanism in vitro. METHODS To assess the possible interactions between UTI...

Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide.

Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation, shock, and pancreatitis in Japan. Recent studies have demonstrated that serine protease inhibitors may play an anti-inflammatory role beyond merely an inhibitory action on neutrophil elastase at the site of in...

Urinary trypsin inhibitor attenuates liver enzyme elevation after liver resection

BACKGROUND Urinary trypsin inhibitors (UTI) have been widely used for the treatment of diseases including disseminated intravascular coagulation, shock, and pancreatitis. Since UTI synthesis is likely to be reduced in patients who have undergone liver resection, the incidence of inflammatory reactions may be increasing accordingly. For such patients, the liver enzyme increases after the operati...

Protective Effects of Urinary Trypsin Inhibitor on Systemic Inflammatory Response Induced by Lipopolysaccharide

Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used in Japan as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation (DIC), shock, and pancreatitis. Recent in vitro studies have demonstrated that serine protease inhibitors may have anti-inflammatory properties beyond their inhibition of neutrophil elastase at the sit...

Inter- -Trypsin Inhibitor Attenuates Complement Activation and Complement-Induced Lung Injury